Global equity markets suffered sharp losses on Wednesday after technology companies unveiled huge investment plans for artificial intelligence infrastructure, triggering investor concerns about profitability and the long-term sustainability of such spending. As a result, the combined market value of major Big Tech firms has fallen by more than $1 trillion over the past week, with shares of companies such as Amazon and Oracle coming under particularly strong pressure.

The U.S. Department of Agriculture has announced that it will release hundreds of millions of sterile, fluorescent New World screwworm flies along the Texas–Mexico border to maintain a barrier preventing the parasitic fly from spreading north. The move comes in response to a growing outbreak in Mexico and the serious threat the pest poses to livestock, the agricultural economy, and public health.

A US federal vaccine advisory committee has announced that it will re-assess all existing vaccination recommendations. Statements from its new chair have triggered strong reactions from the public-health community, which warns that a shift in the committee’s operating philosophy could accelerate declines in vaccination coverage and increase outbreaks of infectious diseases in the United States.

Amazon is planning another major round of layoffs among its corporate staff, expected to begin as early as next week and affect thousands of positions. The move is part of a broader plan to cut nearly 30,000 roles across its global corporate workforce, representing close to 10% of all white-collar employees at the company. If fully implemented, it would mark the largest round of job cuts in Amazon’s history.